Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
This year, for the most hotly contested position－one at the Central Committee of the China Democratic League's reception office－there were about 10,000 competitors.
China purchased 141,000 industrial robots in 2017, up 58.1% year-on-year, but foreign brands accounted for nearly three quarters of that, showing that the gap is still widening between Chinese robot makers and their foreign peers.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
10. Computer systems analyst
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
The soaring prices of 2008, when oil reached more than $140 a barrel, will repeat, though not likely in 2014, Mr. Hummel said. The price 'is going to go higher.'
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The developer behind Kinect Disneyland Adventures and Elite: Dangerous is taking the theme park business to the extreme in ScreamRide. The game lets players build outrageous roller coasters, thrill rides and attractions from the ground up and then take them for a test run. The game offers three ways to play: Engineers can construct elaborate rides that test the boundaries of physics and g-forces; Scream Riders get on these rides and experience the thrills and spills first-hand – sometimes resulting in untimely deaths; and Demolition Experts can use any means necessary to tear down an entire amusement park. With classic PC games like Roller Coaster Tycoon now playable on smartphones, this next generation of thrill-ride creator is a welcome interactive experience. It’s always fun to build, ride and destroy roller coasters – and ScreamRide offers plenty of ways to share the thrills with your friends.
Trends and targets in antiviral phototherapy
This 1977 file photo shows Apple co-founder Steve Jobs as he introduces the new Apple II in Cupertino, Calif.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
不过，更大的尺寸将会对iOS 7和开发人员施加额外压力——后者必须找出方法，使自己的应用程序适用于更多配置规格。而另一方面，这些额外的规格也将为应用程序提供一些更为激动人心的机遇，我们应该能看到iOS 8将包含诸多可适应多屏幕规格的功能。
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
“We know the Netherlands and the Dutch from the Srebrenica massacre,” Mr Erdogan said, invoking the most shameful episode in modern Dutch history. “We know how rotten their character is from their massacre of 8,000 Bosnians there.”
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
D'ALOISIO HAS BEEN quoted opining that 'time is the new currency.' It's the driving notion behind Summly. It's also a strangely wise observation from a 17-year-old. At that age, many of us had more time on our hands than we knew how to fill without plummeting into severe boredom. It's easy to forget-conversing over lunch in a London caf钼 or strolling through the Tate Modern-that D'Aloisio was born in 1995 and has not yet graduated from high school. Or that he still lives in his childhood bedroom, in a cozy upper-middle-class home. As I chat with his parents, he excuses himself to work on his computer. Slouching down the hall in his stocking feet, hems of his skinny jeans brushing the hallway carpet, it is the most kidlike you will ever see him.
A lone European telephone bidder paid a top price of 9.1 million for a smaller 1825 version of John Constable’s admired but difficult-to-love 1824 vertical landscape, “The Lock,” that had been in the same British family since 1855.
Influenza neuraminidase: A druggable target for natural products
There are no right or wrong answers, just be honest with yourself.
She has also performed on Jimmy Kimmel and The Ellen Show - not bad for someone who hasn't even hit adolescence.
Harry Styles, 'Harry Styles'
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
But the developments also point to the vast gap in the use of such cases between the US and EU, where a debate is under way over whether to grant China “market economy” status in the World Trade Organisation, a concession that would make it even harder to bring anti-dumping cases.
The role of biosensors in the detection of emerging infectious diseases
The film version of the popular television series "Legend of Sword and Fairy", also known as Chinese Paladin starts shooting in Zhejiang Province today.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
'It's all bullshit. It's a lie. It's a Band-Aid lie to make them feel better. I know these people, I know they're lily-livered, and as long as it looks good on the surface, to them, that's enough.'
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
5. 范冰冰 1700万美元
Bedrooms are up a curving staircase. A loft-like library overlooks the central atrium. Walls of glass in the master suite and its en-suite bathroom take in acres of marshland. The suite opens to a sun deck on the water side of the house. Both other bedrooms also have en-suite bathrooms. The lower level is finished as a gym, with a half bath and a garage with space for several cars.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The fall in profits in December highlights the challenges facing an industrial sector racked by overcapacity and falling prices, adding to pressure on authorities to loosen monetary policy and boost infrastructure spending to cushion the slowdown.
Dealers: Car dealers work toward reducing the paperwork involved in buying a car and the hours it takes to fill it out. That will give them more time to devote to upselling add-ons such as extended warranties, paint and fabric protection, and rust-proofing.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Will Indian Prime Minister Narendra Modi try any more unorthodox economic experiments
Inhibition of SARS coronavirus helicase by bismuth complexes
Directing for a Comedy Series: Jill Soloway, “Transparent” (“Man on the Land”)
However, significantly fewer women (59 per cent) occupy positions as department heads or above than men (68 per cent) three years after graduation.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
内森是少数几位在夜间拍卖会上积极出价的交易商之一。他在佳士得的拍卖会上代表一位客户以50.65万英镑拍下了查尔斯-安东尼·夸佩尔(Charles-Antoine Coypel)1737年的画作《阿米达宫的毁灭》(The Destruction of the Palace of Armida)，售价是预估价的两倍。
Loyal employees of this auto services company are rewarded on their 10th anniversary -- and every five years after --with a weekend getaway at a resort in Boca Raton, Fla. (The company is headquartered just 15 minutes away.)
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
At the forum, tech entrepreneurs also shared their views on virtual reality, which they said will be the most important computing platform over the next five to 10 years.
14. 《与外婆同行》(Grandma)，导演：保罗·韦兹(Paul Weitz)。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Episodic memory is also known as long-term memory, and the researchers approached the study of exercise in a different manner than previous studies. Other studies examined the impact of aerobic exercise conducted over many months, but this study simply asked participants to lift weights a single time. During the test, half of the participants were asked to use a weight machine before recalling a series of images they were shown at the start of the test. The other half of the participants were also asked to recall the images but without having engaged in any strenuous activity before the recall session. In demonstrating the memory improvement for the participants who engaged in just a single session of weight lifting, the researchers were able to show that improving one's memory through exercise didn't take hours of dedication in the gym. The next time you have the opportunity to lift weights or someone tries to convince you to join the gym you might just want to take him or her up on the offer.
"Poverty has stunted further growth in Internet users, which has kept the Net user population to around 50 percent," Li said.
The real Irving is named Mel Weinberg, and he and his mistress were in fact enlisted by the FBI to oust eight elected officials for taking bribes. Just like the film, Weinberg and the FBI developed an elaborate con to catch the corrupt politicians in the act. Weinberg did end up forming a friendship with one of the officials, although unlike in the film, his final immunity deal didn't protect the friend he helped implicate. Some things are just too far-fetched, even for a career criminal.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Local farmers must love this wireless company as much as its employees do. Once a week, San Diego-based Qualcomm hosts a farmers market at two of its locations. Items sold range from traditional produce to jams and jellies. Employees with CSA veggie box subscriptions can pick up their produce packages at one of the HQ's cafés.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Norway, which has twice rejected European Union membership, ranks No. 10 overall. The country takes the No. 1 spot in Citizenship and the No. 2 spot in Most Transparent.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
此次涵盖95个项目（去年为90个）的排行榜中，来自7个国家的9所院校为首次进入榜单。排名第41位的法兰克福金融管理学院(Frankfurt School of Finance & Management)是今年排名最高的新入榜者。这家德国学院拥有性别比例最平衡的项目之一，女性占学员总数的49%。
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
On average, executive pay packets hit 7.09 million yuan in 2016, up 8% year-on-year, higher than the rate of China's GDP and per capita disposable incomes, which were 6.7% and 6.3% respectively.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Uruguay owes much of its success not just to its passion for football but also to the early inclusiveness of its culture. In that 1950 tournament, at a time when neighboring Brazil still regarded its black players with suspicion, Uruguay boasted a black captain, the brilliant Obdulio Varela. Moreover, Uruguay's victories in the World Cup's formative years established a pedigree that endures to this day, with many of its footballers -- such as Liverpool's Luis Suárez and Paris Saint-Germain's Edinson Cavani -- playing abroad for some of the world's biggest clubs.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Bernard Baumohl 作为Economic Outlook Group的首席经济学家，表示他甚至更乐观的认为接下来的两年将会成为至少近十年以来形势最好的两年，他还称“有很多证据充分的表明了经济正在恢复的势头”。
1. Bottoms Up Beer System
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
If you are working your butt off and not getting paid enough to pay your bills, you might be overqualified and underpaid for your position. Go find a job that pays what you deserve.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Taylor Swift vs. Katy Perry
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
2) I Trust Your Judgment: Translation: “You have my permission. I believe in you. Now, go make it happen.” Feels pretty uplifting to hear that, doesn’t it? And I’ll bet you’d do almost anything to please someone who makes you feel that way. Your employees and peers are no different.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The survey by the Public Religion Research Institute in partnership with the Religion News Service found political and religious disagreement on what is behind severe weather, which this year has included extreme heat and drought.
China has recently made majordecisions about its economic future. On November 15, 2013, China announceddramatic new social and economic policies contemplating much greater relianceon market forces than it has in the past and inviting private-sectorparticipation and foreign competition in industries long previously controlledby the central government. It also relaxed its one-child policy, openingthe country and its people to vast new opportunities and inspiring new hopes anddreams.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
3.You Spend More Time Surfing the Web Than Doing Your Job
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
葡萄牙诺瓦商业与经济学院(Nova School of Business and Economics)巩固了去年的强劲表现，排名进一步攀升14个位置，排在了第17位。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
adj. 在 ... 之前，先，前，以前的
A modular microarray imaging system for highly specific COVID-19 antibody testing
EMBAGlobal is the only programme in the top 10 that saw a slight drop in the average salary of its alumni compared with last year (the other nine recorded strong increases).
Interviewers made their share of blunders, too.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Social scientists, after crunching data from both sides of the Atlantic, have discovered something surprising: it’s not the amount of racial or ethnic diversity in a community that predicts white resentment and support of anti-immigrant policies, but the pace of change.
Epic is not OK with ongoing cheating or copyright infringement from anyone at any age, it said.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
《在生前留下的物品中回忆世界上最长寿的人》(Remembering the World’s Oldest Person, in the Objects She Left Behind)
Alternative fuels: For the first time since diesel-powered cars from Europe started arriving here in the 1950s, old first-person accounts about the joys of driving a diesel fall off to near zero. They are replaced by new first-person accounts about the joys of driving cars with ridiculously high horsepower like the 580-hp Chevrolet Camaro ZL1 and Dodge’s Challenger SRT Hellfire with 707 hp. Elsewhere: fuel-cell cars with their longer cruising range move center-stage, stealing the limelight from battery-powered cars.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The .40-calibre Smith & Wesson that killed her, a semi-automatic handgun, was seized by police to undergo ballistics testing to determine if it had been used in other crimes.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
2005年，戴维森发现自己总是得跟在一岁大的儿子杰克后面，收拾他随处乱扔的儿童吸管杯。于是，她从塔吉特（Target）上买了一台缝纫机，为儿童吸管杯设计出一个类似皮带的奇妙装置——SippiGrip。但她并没有很快实现自己的创业梦想——她加入了微软人力资源团队，与X-Box部门合作。2007年，她在全国性贸易展上推出了SippiGrip。幸运的是，塔吉特邀请她参加2008年父母发明产品计划。目前，戴维森的产品已经在沃尔玛（Walmart）、婴儿反斗城（Babies "R" Us）和亚马逊等零售商开卖。
A facile assay for rapid detection of COVID-19 antibodies
Jackdaw Research的简?道森(Jan Dawson)表示，最近几个月“他表现得更加意气风发和充满自信”。
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
China Hyundai dealers seek up to $135 million compensation
"We have called the police and collected evidence to protect the company's reputation. Those who leaked the nude pictures will be punished according to law," the announcement read.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The future is always bright if you are an entrepreneur, and the opportunities to create new ventures based on the digitisation of age-old services has a long way to run.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
STEP 9: BE SURE to tell everyone to shut up on a daily basis, it's endearing you know
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Meanwhile, villages within the city's boundaries will be overhauled and low-end manufacturers and logistics companies removed.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
1. Peaceful Era
Anti-HIV drug repurposing against SARS-CoV-2
Some 695 million netizens used mobile phones to access the Internet in 2016, with a growth rate exceeding 10 percent for the third straight year, the report said. Smartphone-based Internet use accounted for 95.1 percent of all Internet users, up from 90.1 percent in 2015.
Homeowners in neighborhoods like the Grand Concourse in the Bronx or Elmhurst in Queens could enjoy new attention from buyers eager to find the next untapped market. “When have you heard talk about Kingsbridge in the Bronx?” asked Ms. Ramirez of Halstead. “The people who are smart are getting out there and buying it up at wonderful prices.”
Length-scale dependence of protein hydration-shell density
《国土安全》(Homeland)：第三季末布洛迪（Brody，戴米恩·路易斯[Damian Lewis]饰）最终被杀后，映时频道(Showtime)的这部间谍惊悚剧似乎走到了尽头。目前看来，第四季没了他却变得充满活力，令人喜爱。卡莉（Carrie，克莱尔·丹尼斯[Claire Danes]饰）这次的对手是美貌、狡猾的巴基斯坦情报官塔斯尼姆（Tasneem，尼姆拉特·考尔[Nimrat Kaur]饰）。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
We need to ensure that our consumers will have access to good options, benefit from such consumption, and most importantly that Chinese companies will be able to win over the consumers with their commitment to high quality and workmanship.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
For all of the acceptance speech kerfuffle when Gwyneth Paltrow won best actress for her role as Viola de Lesseps in John Madden’s 1998 film Shakespeare in Love, the Hollywood star has since said she keeps the award tucked away – “the thing freaks me out”.
Nicolas Cage certainly bucks a lot of trends. He once told media that, for residency reasons, the award he won for the 1996 film Leaving Las Vegas was “in a truck somewhere moving through Louisiana”. Apparently, one of the ways the authorities determine if you’re a resident or not – in what must be the most niche of tests – is to ask where your Academy Award is.
7. Viceroy's House
About this collection
This year, pop's best albums came from strong women who had a lot to say: Lorde's searing look at loneliness, Kesha's raucous statement of liberation, Taylor Swift's reckoning between her self and the version presented in the press.