Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Summly attempts to solve this problem by creating “snapshots” of stories that allow readers to browse more quickly than reading full articles. The app will close down but Mr D’Aloisio’s technology will be integrated into Yahoo’s mobile apps.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
4. "The Big Bang Theory" (3.4 million)
Sometimes bosses suck. But if your boss sucks all the time and takes advantage of your time, it's time to find a new job.
Trends and targets in antiviral phototherapy
We will push forward with structural adjustment in agriculture.
Most remittances ($117 billion) came from the United States, followed by Europe ($115 billion) and the Gulf states ($100 billion).
This pseudo-comedic 1970s crime drama tells the story of two romantically involved con artists named Irving Rosenfeld and Sydney Prosser, who are caught by an FBI agent and forced to scam corrupt politicians. The two continue to manipulate the FBI agent, their political targets, and their own family members, ultimately cutting an immunity deal that allows them to escape the ordeal without any criminal charges.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Some would argue that Carly Simon's theme to The Spy Who Loved Me is the best James Bond theme song ever. They may have a point, but maybe what's really going on is that this is just "the best song from a James Bond movie." It's a fun tune, catchy as hell, romantic and beautifully sung. But nothing about this seems to specifically evoke James Bond, his adventures, his history or even his films. "Nobody Does It Better" is still a winner by any estimation; there's just happens to be a reason why it didn't crack our top five.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
The parents of a number of stars have ended up with their Oscar-winning child’s awards. Angeline Jolie’s late mum, for a number of years, had the best supporting actress award her daughter won for her role as the troubled Lisa Rowe in Girl, Interrupted. Nicole Kidman’s best actress Oscar for The Hours now sits on her parents’ mantelpiece in Sydney, where neighbours apparently pass by for visits. Hollywood’s darling du jour, Jennifer Lawrence, keeps the award she won last year for her leading role in Silver Linings Playbook on top of her parents’ piano at home in Kentucky.
ACE2 as a potential therapeutic target for pandemic COVID-19
The high-end model is an addition to Apple’s line-up, alongside more incremental updates to the iPhone 7 and 7 Plus released last year.
Unfortunately, there won't be a 2014 rematch between Brazil and Uruguay, as the latter was eliminated on Saturday. If Brazil makes it to the final on July 13, the country could play Mexico, the Netherlands, Costa Rica, Greece, USA, Belgium, Argentina or Switzerland.
Diagnostic technologies for COVID-19: a review
My heart is my New Year present to you.我的心就是我奉献给你的新年礼物。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
“This is a historic moment for Puerto Rico,” said 50-year-old Jose Davila as he waved a large flag from Rossello’s pro-statehood party. “He’s the hope of our island, he’s the hope for statehood, he’s the hope for a people that have suffered.”
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
当你听说今年3月份，一个17岁的学生把自己设计的一款软件以3,000万美元卖给雅虎公司(Yahoo! Inc., YHOO)的时候。对于这孩子的形貌，你脑海里或许已勾画出一个搞笑的形象了吧：不用说，肯定是个极客。一个除了一行一行写代码之外对什么也不感兴趣的学霸。一个不敢正眼瞧人还老小声儿嘀咕着什么的神经质。
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
An ancient Egyptian amulet was uncovered in Jerusalem by a young girl taking part in a family dig in the capital.
Antiviral drug discovery: broad-spectrum drugs from nature
Season\'s greetings and best wishes for the New Year.
Tiemba scores highly forinternational experience, being delivered half on Tsinghua’s campus in Beijing as well as on Insead’s three campuses in Singapore, France and the UAE.
Influenza neuraminidase: A druggable target for natural products
"Pandas used to be really difficult to breed in captivity, but the Chengdu base and other zoos around the world have cracked the problem and now there are around 400 in captivity," Mr Marven said.
I am afraid to go out in the sun now because of the holes in the ozone. I am afraid to breathe the air because I don't know what chemicals are in it. 我现在害怕晒太阳，因为臭氧层出现了空洞。我现在害怕呼吸空气，因为我不知道那里有多少化学物质。
The dollar value of China’s exports fell markedly more than expected last month and import growth more than halved, while revisions to November data erased what had appeared to be a long-hoped-for return to growth for outbound shipments.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Stevens会演唱电影《以你的名字呼唤我》中《Mystery of Love》，以及Bernal, LaFourcade和 Miguel会合唱《寻梦环游记》中的歌曲《Remember Me》。
Productivity is the name of the game for entrepreneurs. The good news is that there are thousands of amazing software applications out there, designed to make your life easier. The bad news is that you don’t have time to try thousands of software applications. Which ones are worth your time?
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Fluctuations of the markets led to a tightening of IPO approval to maintain stability, according to Frank Lyn, PwC China's mainland and Hong Kong Markets Leaders.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
得克萨斯州成为首批摆脱经济衰退的州之一，该州凭借低税收负担、监管环境可预见性和熟练劳动力不断吸引企业投资。根据穆迪分析公司的统计，得克萨斯州的就业人数到2017年将以每年3%的速度增长。（亚利桑那州的预计就业增长速度仅高出0.04%）。得克萨斯州吸引了众多加利福尼亚州企业的关注，得州州长里克?佩里（Rick Perry）毫不顾忌地把两个州的商业环境相对比。最近几年来，加州企业电子港湾（EBay）和电子艺界（Electronic Arts）都选择在得克萨斯州大举扩张。奥斯汀一直是商业活动的温床，今年埃森哲咨询公司（Accenture）、AT&T公司、国家仪器公司（National Instruments）和时代华纳有线（Time Warner Cable）都宣布计划在该地区大幅增加就业岗位。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
“Lotte will hurt the Chinese people and the consequences could be severe,” said the report, which followed a string of government probes into the company’s business interests in China.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Ujiri's well-timed and thoughtful moves should help reverse the Raptors' backsliding.
Germanyjust hung four onPortugal. It was a bit of a shocking result, at least from the perspective that most observers expectedPortugalto put up a bit more fight. But it was another relatively high-scoring game at World Cup 2014? Not surprising at all.
But he told Washington's Observer-Reporter paper that he was keen to read it as it was "a testament of the sincerity, interest and innocence of that time".
As for China, lack or stopped development represents the biggest risk for this country. So it is essential that we maintain steady medium-high growth of our economy and that in itself is China’s contribution to global stability.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Soon after he finished his duties, Sun heard loud voices coming from outside.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
For democrats, the outburst of such primal emotions is disturbing because they are so hard to contain.
11. “The Black Panthers: Vanguard of the Revolution” (Stanley Nelson)
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The University of St Gallen remains top overall, the seventh consecutive year that the Swiss school’s MA in Strategy and International Management has headed the ranking. HEC Paris stays in second place, a position it has held since 2014, while Spain’s IE Business School jumps four places to third.
“What we are seeing right now from China is not only a phenomenon for Brazil, we are seeing the same all over Latin America, declining [Chinese export] volumes into all the markets,” said Antonio Dominguez, managing director for Maersk Line in Brazil, Paraguay, Uruguay and Argentina. “It has been going on for several quarters but is getting more evident as we move into the year .”
About 980 million yuan of illicit assets were recovered, according to the Communist Party of China Central Commission for Discipline Inspection.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
最近的一个例子是：当格温o史蒂芬尼发布新专辑《 Spark the Fire》时，Swyft公司即时设计了一个免费贴纸包，在自己的几个短信应用中推出。它被下载了近一百万次，并在用户中传送了七百万次，最后在10天内被观看了4100万次。雷表示，对任何品牌来说，要在其他渠道达到这样的广告效果，需要花上5万到25万美元。
No Bad Manners Awards could be complete without a mention of a Kardashian, could it?
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
7. Cannes' 'year of women' didn't go so well
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The January-to-November period in the United States this year was the warmest first 11 months of any year on record for the contiguous states. And 2012 will likely surpass 1998 as the warmest year on record for the nation, according to the National Oceanic and Atmospheric Administration.
GM is addicted to hefty sales incentives to move the cars and new CEO Ed Whitacre knows it. In 2010, he will slash incentives and end up abandoning GM's 20% U.S. market share target to find profitability. The search will prove elusive.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The big question is what oil prices will do in 2015. Oil prices are unsustainably low right now – many high-cost oil producers and oil-producing regions are currently operating in the red. That may work in the short-term, but over the medium and long-term, companies will be forced out of the market, precipitating a price rise. The big question is when they will rise, and by how much.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Despots use the former as an excuse for repression and the latter to demand absolute obedience.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
People on both sides of the Taiwan Strait are brothers and sisters, and no matter how the situation on the island evolves, the mainland is determined to maintain Cross-Strait stability.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
“…called the interviewer by the wrong name.”
Set between the events of Star Wars Episode III and IV, Rogue One will most likely be about bounty hunters who set out to steal the Death Star plans. We're not exactly sure of the plot.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The Glory of Tang Dynasty
More than 27,000 vacancies are offered by over 120 central departments and their affiliated public institutions in the 2017 civil servant recruitment drive. The number of vacancies is about the same as 2016.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Chinese people are intelligent and hardworking and they have an inexhaustible drive for pursuing a better life for themselves. The government needs to create the enabling environment for our people to fully use their talent and initiative.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Security questions risks
4. Slacking at school
A modular microarray imaging system for highly specific COVID-19 antibody testing
Golden State equaled the 1957-58 Celtics as the only defending champions to win their initial 14 games. The Warriors are one of five teams in NBA history to begin 14-0, and will travel to Denver looking to keep it going Sunday.
此次涵盖95个项目（去年为90个）的排行榜中，来自7个国家的9所院校为首次进入榜单。排名第41位的法兰克福金融管理学院(Frankfurt School of Finance & Management)是今年排名最高的新入榜者。这家德国学院拥有性别比例最平衡的项目之一，女性占学员总数的49%。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
vt. 作 ... 姿
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Migrants working in rich countries sent home almost half a trillion dollars in 2016, helping to lift families out of poverty by providing financial stability, access to education, housing and healthcare, according to a global report.
One suggested change: require rent-stabilized tenants to verify their income.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
9. 《奎迪》(Creed)，导演：瑞恩·库格勒(Ryan Coogler)。
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
As a result, his position on the Forbes' ranking dropped 220 spots, leaving him tied with 19 others as the 544th richest person in the world.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Despite the overall upward trends in financing, the amount of capital raised by women-owned businesses has historically lagged when compared to men. For example, in the first half of 2013, women made up only 16 percent of businesses seeking funding, with only 24 percent of the women receiving angel funding, Plum Alley, an online e-commerce platform for female entrepreneurs, recently launched a crowdfunding platform specifically focused on helping women innovators get to the next level. And as the first platform of its kind in the exploding crowdfunding space (expected to hit $3.98 billion next year), we can certainly expect Plum Alley to play a big role in the entrepreneurial landscape for women in the year to come.
Morgan Stanley’s Jonas believes the Model X will sell more based on features like its upgraded infotainment system unique “falcon-wing” back-seat doors than fuel economy and he will be disappointed if the Model X doesn’t win every major car of the year award. He isn’t alone. So will Elon Musk and a whole lot of Tesla investors who pray that the momentum behind this amazing stock keeps building.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Directing for a Mini-Series or Movie: Susanne Bier, “The Night Manager”
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Buyers and Sellers
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
We will take solid steps to pursue a new type of urbanization.
Anti-HIV drug repurposing against SARS-CoV-2
2015年英国《金融时报》全球高管工商管理硕士课程(Global Executive MBA，简称全球EMBA)排行榜由于两个原因而引人注目。不仅因为这是英国《金融时报》发布的第100个商学院排行榜，也是因为今年首次有一个主办方包含一所中国内地商学院的项目拔得头筹。
“A worker sent a text to a colleague saying he was quitting and asked her to forward it to management.”
Length-scale dependence of protein hydration-shell density
I, however, am not among them.
But yeah, of course they should tank. And so should the Kings. Again. And the Heat. And the Magic. These are mediocre teams, at best, without high upsides even in the most optimistic projections.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
1.It wasn’t me! – Because some things just aren’t worth taking credit for。
1. The remote control belongs to me for the whole month.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
达洛伊西奥的父母从澳大利亚搬到英国，他的父亲卢(Lou)曾在英国石油(BP)和摩根士丹利(Morgan Stanley)工作，而母亲戴安娜(Diana)是一位企业律师，同时也是儿子的合同代表。他们向来都知道达洛伊西奥是一个非常好学的孩子。但戴安娜说因为他是长子，他们本以为他不会做出什么超出寻常的事情来（达洛伊西奥有一个14岁的弟弟）。他们强调，尽管达洛伊西奥成就非凡，尽管他聊天时会聊起马尔科夫模型(Markov models)和随机过程(stochastic processes)，他仍只是一个再普通不过的孩子。戴安娜说，他周末仍要出去玩，仍要去参加派对。他还有个女朋友。17岁孩子会做的事情，他都会做。
For the first time in six years, a new challenger has topped the FT’s ranking of executive MBA programmes.
About this collection
2. "Breaking Bad" (4.2 million)